Fibroblast growth factor receptor 3...
AKA CD333.
R&D Systems seems to have the only clone specifically marketed for flow cytometry.
Santa Cruz Biotech has SU5402 in RUO format.
Chesi et al. posit that it's an oncogene for multiple myeloma: "Myeloma cells carrying a t(4:14) translocation express a functional FGFR3 that in some cases is constitutively activated...". Zhihua Li et al. declare that circulating tumor cells from mice with FGFR3-TD expression in the bone marrow "revealed a pre-B-cell pheotype... although immature T-lymphoid or mature myelome populations also predominated in some animals". Jun-Hyeog Jang et al. identified "two novel mutations of FGFR3 in colorectal carcinomas." Joshua L Patterson et al. looked at FGFR3 inhibitor SU5402. It seems to inhibit receptor-dependent growth of human MM cell lines via cell cycle arrest and increased apoptosis. Patterson laments that "given the difficulty in establishing [primary myeloma cell cultures] under physiologically relevant conditions, we believe that only clinical trials of FGFR3 kinase inhibitors will formally establish the role of such drugs in MM therapy."
And now for some flow:
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2006.06479.x/pdf
http://clincancerres.aacrjournals.org/content/17/13/4389.full
From the Chandesris paper, plotting of FGFR3 data.
Comments